| It is also apparent that some symptoms occur immediately or soon after exposure, for example, many of the irritant, gastric, nervous and respiratory effects. However, others, such as nervous system impairment, immunosupression and chemical sensitivity, develop later, perhaps months after exposures may have ceased. Further, while some of these symptoms are fully reversible, others appear to persist for longer (in some of the longer cases, for at least five years). Debate is also continuing about the links between exposure and some of longer-term symptoms (such as chemical sensitivity).
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| Symptom severity depends on a number of factors, including the range of contaminants present, the intensity, duration and frequency of exposure, toxicity of compounds (expectedly influenced by cabin environment factors such as humidity, decreased oxygen concentration and contaminants such as carbon monoxide), and individual susceptibility. |
